The Ellis laboratory strives to understand mechanisms that maintain genomic integrity & their relationship to cancer susceptibility. We are particularly interested (i) in regulatory mechanisms that control the integrity of the replication fork & that respond to genotoxic agents & (ii) in genetic factors, particularly ones involved in maintaining genomic intregrity, that impact colorectal carcinogenesis, both germ-line risk & somatic development in cancer.
The Maggert laboratory uses model organisms and human tissues to understand epigenetic instabilities in cancer. Epigenetic instabilities result in inappropriate changes to gene expression patterns, cell identities, and genome integrity, yet the genetic and environmental causes of epigenetic instabilities are almost entirely unknown. We explore the basic biology in the exquisitely experimentally manipulable fruit fly Drosophila, then apply that knowledge to understanding the risk, onset, and progression of human breast and blood cancers.
Welcome to the Instability in Cancer & Epigenetics Research Group website. The iceberg peak represents the amount of that we truly know. Beneath the surface, there is so much that remains unknown. We explore this unknown, that which lies beneath the tip of the iceberg.
Destroy the dogma!
Tease out the mechanisms!
Change lives forever!
-Gaius Augustus & Nathan Ellis
"Supplanting existing paradigms to obviate current roadblocks and open the way for new strategies for diagnosis, interventions, and treatments." -Keith Maggert
Nuking existing paradigms to annihilate boundaries of knowledge and make history.